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Azulfidine (Sulfasalazine) Side Effects


Updated July 20, 2013

Common Side Effects:

Check with your doctor if any of the following side effects continue or are bothersome:

  • abdominal or stomach pain or upset
  • diarrhea
  • loss of appetite
  • nausea or vomiting

Notify Doctor Immediately:

More common

  • aching of joints
  • headache (continuing)
  • itching
  • increased sensitivity of skin to sunlight
  • skin rash
Less Common or Rare
  • aching of joints and muscles
  • back, leg, or stomach pains
  • bloody diarrhea
  • bluish fingernails, lips, or skin; chest pain
  • cough
  • difficult breathing
  • difficulty in swallowing
  • fever, chills, or sore throat
  • general feeling of discomfort or illness
  • loss of appetite
  • pale skin
  • redness, blistering, peeling, or loosening of skin
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • yellow eyes or skin

Other notes:

In some patients this medicine may also cause the urine or skin to become orange-yellow. This side effect does not need medical attention.

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor. This information is meant only as a guideline -- always consult a physician or pharmacist for complete information about prescription medications.

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