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Side Effects - Azathioprine [Imuran]

By Amber J. Tresca, About.com

Updated October 17, 2004

About.com Health's Disease and Condition content is reviewed by the Medical Review Board

Common Side Effects:

Check with your doctor if any of the following side effects continue or are bothersome:

  • loss of appetite
  • nausea or vomiting
Less common:

Check with your doctor if any of the following side effects continue or are bothersome:

  • Skin rash
Always Notify Doctor:

More common

  • Cough, hoarseness
  • fever or chills
  • lower back or side pain
  • painful or difficult urination
  • unusual tiredness, weakness

Less Common

  • Black, tarry stools
  • blood in urine or stools
  • pinpoint red spots on skin
  • unusual bleeding or bruising

Less Common or Rare

  • Fast heartbeat
  • fever (sudden)
  • muscle or joint pain
  • nausea, vomiting, and diarrhea (severe)
  • redness or blisters on skin
  • shortness of breath
  • sores in mouth, on lips
  • stomach pain
  • swelling of feet or lower legs
  • feeling of discomfort or illness (sudden)

Other Notes:

Your doctor will watch for any liver problems this medicine may cause.

Because of the way this medicine acts on the body, there is a chance that it might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia, lymphoma, or skin cancer. The risk of cancer is lower in people taking azathioprine for arthritis, and you should discuss these possible effects with your doctor.

After you stop this medicine, there may still be some side effects. During this time notify your doctor as soon as possible if you notice any of the following:

  • black, tarry stools
  • blood in urine
  • cough or hoarseness
  • fever or chills
  • lower back or side pain
  • painful or difficult urination
  • pinpoint red spots on skin
  • unusual bleeding or bruising

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor. This information is meant only as a guideline - always consult a physician or pharmacist for complete information about prescription medications.

Return to Medication Side Effects Index

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