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Zelnorm (Tegaserod) Frequently Asked Questions
Side effects, use during pregnancy and drug interactions for this IBS drug.

By Amber J. Tresca, About.com

Updated April 18, 2008

About.com Health's Disease and Condition content is reviewed by the Medical Review Board

What is Zelnorm?

Zelnorm (Tegaserod) works by increasing the effect of serotonin, a chemical naturally found in the body, on the intestines. This results in stool moving through the intestines more normally and preventing constipation.

How is Zelnorm taken?

Zelnorm comes in the form of a 6 mg tablet and is normally taken twice daily on an empty stomach shortly before a meal.

Why is Zelnorm prescribed?

Zelnorm is prescribed for women who have constipation-predominant irritable bowel syndrome (C-IBS). This drug is not approved for use in men, as it has not been shown to be effective. Zelnorm is not approved for use in children under the age of 18 years.

What do I do if I miss a dose?

If you miss a dose, take it as soon as you remember. If your next dose should be taken soon, just take that dose. Don't double up, or take more than one dose at a time.

Who should not take Zelnorm?

Tell your doctor if you have ever had any of the following conditions:
  • Abdominal adhesions
  • Bowel obstruction
  • Frequent diarrhea
  • Galbladder disease
  • Liver or kidney disease
  • Sphincter of Oddi dysfunction

What are the side effects?

A common side effect is diarrhea which may begin during the first week of treatment but improves with continued treatment. However, abdominal pain or cramping and dizziness occurring with severe diarrhea should be reported to the prescribing physician.

Other side effects can include dizziness, headache (migraine), stomach pain, back pain, joint pain, nausea, and gas. See the Zelnorm side effects page for a complete list.

What medications can Zelnorm interact with?

Current studies have not shown Zelnorm to interact with any other medications.

Are there any food interactions?

Zelnorm is not known to interact with any foods.

Is Zelnorm safe during pregnancy?

The FDA has classified Zelnorm as a type B drug. The effect that Zelnorm has on an unborn child has not been studied extensively. Zelnorm should only be used during pregnancy if clearly needed. Notify the prescribing doctor if you become pregnant while taking Zelnorm. It is not known if Zelnorm passes into breast milk and breast-feeding women should talk to their physician before taking it.

How long can Zelnorm be taken safely?

Zelnorm is normally prescribed initially for 4 to 6 weeks. Symptoms of C-IBS may start to improve in 1 to 2 weeks. Zelnorm is a new drug, so its long term use should be determined by a physician.
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