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St. John’s Wort May Interfere With Some Prescription DrugsACS NewsToday August 9, 2000
The Food and Drug Administration (FDA) issued a public health advisory on St. John's Wort after reviewing a study by the National Institutes of Health (NIH). It was discovered that St. John's Wort may interfear with some prescription drugs including indinavir (used to treat HIV), and cyclosporine (used for organ transplant rejection and for Inflammatory Bowel Disease).
St. John's Wort has been proven to be effective in treating mild to moderate depression. The NIH is conducting a clinical trial on the active ingredient in St. John's Wort - hypericin. Potency and purity listed on labels of the herb vary widely, sometimes lower than what is listed on the label.
Long term effects of St. John's Wort are unknown. It should not be used in conjunction with anti-depressants, alcohol, narcotics, amphetamines, anticoagulants, antibiotics or cold and flu medicines that contain pseudoephedrine.
St. John's Wort Revisited
What you need to know before taking St. John's Wort.