Crohn's disease is a chronic disease that can cause inflammation anywhere along the digestive tract from the mouth to the anus.
Unlike ulcerative colitis, which only affects the inner layer of the digestive tract, Crohn's disease commonly involves all layers of the intestinal wall. Crohn's disease and ulcerative colitis are collectively called inflammatory bowel disease (IBD).
- Abdominal pain and cramps
- Bloody stool
- Loss of appetite
- Mucus in the stool
- Ulceration of the digestive tract
One theory about the cause of IBD is that it could be an allergic response, largely based on the fact that IBD is an autoimmune disease. Environmental factors have also been implicated, but there is no consensus in the medical community as to exactly which factors might influence the onset of IBD.
The true cause of IBD could still be any combination of these, or even a causative agent that is yet undiscovered.
Colonoscopy may be used to look inside the colon to see if inflammation is present, or an upper endoscopy may be done if disease in the upper digestive tract is suspected. Several other tests such as x-rays, barium enema, upper gastrointestinal series, and sigmoidoscopy may also be helpful.
Blood tests are also commonly done to provide helpful information about the status of IBD, especially red blood cell and white blood cell counts. Other blood tests can measure electrolyte levels, such as sodium and potassium, to determine if they are depleted from persistent diarrhea.
Treatment for Crohn's DiseaseMedication: A variety of medications may be used to treat Crohn's disease. Medications typically fall into two categories: Maintenance drugs, which are taken continuously to prevent flare-ups, and fast-acting drugs, which are taken to stop a flare-up.
Medications frequently used to treat Crohn's disease include: Azulfidine (sulfasalazine); Asacol and Pentasa (mesalamine); Imuran (azathioprine); Purinethol (6-MP, mercaptopurine); cyclosporine; Rheumatrex (methotrexate); Remicade (infliximab); Humira (adalimumab); and corticosteroids (such as prednisone and Entocort EC (budesonide)).
Surgery: Surgery is also used as a treatment for Crohn's disease. Approximately 70% of people with Crohn's disease will have surgery in the first 10 years after diagnosis. Of those, half will have more surgery in the next 3 to 4 years. Resection, where a diseased section of intestine is removed, is the most common type of surgery. Surgery is not a cure for Crohn's disease.
Omega-3 fatty acids have had mixed results as a treatment for Crohn's disease, but they are considered a healthy addition to anyone's diet.
Boswellia (frankincense) has been studied for use in IBD, but it is currently not approved to treat any condition.
Slippery elm has been found to have antioxidant effects, but further study is needed to determine if it is helpful for use in IBD.
Bromelain has shown promise in animal studies, but there are no studies on humans yet.
The most common form of Crohn's disease is ileocolits, which affects the ileum (lower end of the small intestine) and the colon (large intestine). Ileitis, also known as fistulizing or perforating Crohn's disease, affects only the ileum. Gastroduodenal Crohn's disease affects the stomach and duodenum (first part of the small intestine). Jejunoileitis is characterized by intermittent areas of inflammation in the jejunum (middle section of the small intestine). Crohn's colitis, sometimes called granulomatous colitis, affects only the colon and is sometimes confused with ulcerative colitis.
- a young age at diagnosis
- 8 to 10 years of active disease
- incidence of strictures
- history of primary sclerosing cholangitis
Several complications are associated with Crohn's disease, and those that manifest outside the colon are called extra-intestinal complications. Extra-intestinal complications include arthritis, delayed growth in children, eye diseases, gallstones, skin conditions, and mouth ulcers. Most of these complications will worsen when the Crohn's disease is flaring and improve when it is in remission.
Some of the potential local (intestinal) complications of Crohn's disease include abscesses; bowel obstruction; bowel perforation; colorectal cancer; fissures; fistulas; toxic megacolon; and worsening of symptoms during menstruation.