What Is Cyclosporine?
Cyclosporine is a drug that decreases the action of the body’s immune system. It is used frequently in organ or bone marrow transplant patients to prevent rejection. It also is used to treat diseases caused by an "overactive" immune system, such as in patients with Crohn’s disease or rheumatoid arthritis.
How Is Cyclosporine Taken?To keep a constant amount of cyclosporine in the body, it is important to take cyclosporine at the same time each day. Not only is the time of day important, but also when cyclosporine is taken in relation to meals. Food has an effect on the absorption of cyclosporine, so cyclosporine should also be taken each day with the same association to food (ie, either with a meal or at the same interval before or after a meal).
What Do I Do If I Miss A Dose?
If you miss a dose, take it as soon as you remember. If your next dose should be taken soon, just take that dose. Don't double up, or take more than one dose at a time.
Who Should Not Take Cyclosporine?
Tell your doctor if you have any of the following conditions:
- High blood pressure
- Infection: viral, bacterial, or fungal
- Kidney disease
- Liver disease
Tell your doctor if you have ever received treatment with:
- Coal tar
- Radiation therapy
What Are The Side Effects?
Serious side effects of cyclosporine can include fever, chills, sore throat, bleeding or bruising easily, mouth sores, abdominal pain, pale stool, darkened or increased amount of urine, weight loss or gain, muscle spasms or weakness, fast or irregular heartbeat, muscle spasms, confusion, tingling in the hands or feet, problems in hearing, fatigue. Minor side effects can include decreased appetite, headache, nausea, vomiting, diarrhea, upset stomach, acne, cramping, increased hair growth, tremors, gum irritation, dizziness, flushing, and high blood pressure. See the cyclosporine side effects page for a complete list.
Patients taking cyclosporine may be more vulnerable to infection. Avoid persons who are sick with a cold, the flu, or other contagious illnesses, or those who have received a nasal flu or a polio vaccine.
Are There Any Sexual Side Effects?
Cyclosporine is not known to cause any sexual side effects in either men or women.
What Medications Can Cyclosporine Interact With?
Cyclosporine can interact with several drugs. Tell the prescribing physician about all drugs and nutritional supplements you are taking, especially those from the following list that may interact with cyclosporine.
- Antfungals amphotericin B (Fungizone) and ketoconazole (Nizoral)
- Bromocriptine (Parlodel)
- Calcium-channel blockers such as diltiazem (Cardizem, Dilacor XR, Tiazac), nicardipine (Cardene), amiodarone (Cordarone, Pacerone) and verapamil (Calan, Verelan)
- Colchicine and allopurinol (Aloprim, Lopurin, Zyloprim)
- Danazol (Danocrine) and methylprednisolone (Medrol)
- Digoxin (Lanoxin, Lanoxicaps)
- Histamine H2-antagonists such as cimetidine (Tagamet, Tagamet HB) and ranitidine (Zantac, Zantac 75)
- HIV protease inhibitors such as indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), lopinavir-ritonavir (Kaletra) and saquinavir (Fortovase, Invirase)
- Ketoconazole (Nizoral), itraconazole (Sporanox), and fluconazole (Diflucan)
- Macrolide anbitiocis such as erythromycin (Ery-Tab, E-Mycin, E.E.S., P.C.E.) and clarithromycin (Biaxin)
- Melphalan (Alkeran)
- Metoclopramide (Reglan)
- NSAIDs such as ibuprofen (Advil, Motrin, Nuprin), naproxen (Naprosyn, Anaprox, Aleve, others), diclofenac (Voltaren, Cataflam), etodolac (Lodine), flurbiprofen (Ansaid), fenoprofen (Nalfon), indomethacin (Indocin), ketorolac (Toradol), ketoprofen (Orudis KT, Orudis, Oruvail), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), and tolmetin (Tolectin)
- Potassium-sparing diuretics (water pills) such as amiloride (Midamor), spironolactone (Aldactone, Spironol), or triamterene (Dyrenium)<br />
- Prednisolone (Prelone, Pediapred)
- PUVA or UVB therapy
- Statins: lovastatin (Mevacor), fluvastatin (Lescol), pravastatin (Pravachol), simvastatin (Zocor), or atorvastatin (Lipitor)
- Sulfa antibiotics: trimethoprim with sulfamethoxazole (Bactrim, Septra, Sulfatrim), gentamicin (Garamycin), and vancomycin (Vancocin)
- Tacrolimus (Prograf)
Are There Any Food Interactions?
Do not take cyclosporine with grapefruit or grapefruit juice.
Is Cyclosporine Safe During Pregnancy?
The FDA has classified cyclosporine as a type C drug. This means that it is not known whether cyclosporine will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or become pregnant during treatment. Cyclosporine does pass into breast milk and could affect a nursing infant.