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Apriso

This Form Of Mesalamine Is Extended-Release

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Updated February 26, 2013

What Is Apriso?

Apriso is a form of mesalamine that is used to treat inflammation in the colon caused by ulcerative colitis. Apriso contains a patented delivery system for the mesalamine called Intellicor. Intellicor is an extended-release system that allows the mesalamine to travel through the digestive tract and be deployed in the colon, where it is needed. Other brand names of oral mesalamine include Pentasa, Asacol, Colazal and Lialda.

Why Is Apriso Prescribed?

Apriso is approved for use in maintaining remission in patients with ulcerative colitis and proctitis. It is not currently approved for treatment of active disease (a flare-up.)

Who Should Not Take Apriso?

Apriso is not for everyone. Tell your doctor if you have ever had any of the following conditions:
  • Congestive heart failure
  • Kidney disease
  • Liver disease
  • Pyloric stenosis

Is Apriso Safe During Pregnancy?

The FDA has classified Apriso as a type B drug. The effect that Apriso has on an unborn child has not been studied extensively. Apriso should only be used during pregnancy if clearly needed. Notify the prescribing doctor if you become pregnant while taking Apriso. Apriso does pass into breast milk and could affect a nursing infant. Tell your doctor if you are breastfeeding a baby.

What Are the Side Effects of Apriso?

Serious side effects of Apriso include fever, severe headache, and sudden or severe abdominal pain. Minor side effects can include nausea, diarrhea, and headache, which may resolve on their own. See Mesalamine Side Effects for more potential side effects.

Apriso is not known to cause any sexual side effects in either men or women.

How Is Apriso Taken?

If Apriso is prescribed for you, four capsules should be taken daily. Do not crush or chew the tablets, as this can cause the mesalamine to be released earlier in the digestive tract than the colon. The capsules can be taken with or without food.

What Do I Do if I Miss a Dose?

If you miss a dose, take it as soon as you remember. If your next dose should be taken soon, just take that dose -- don't double up, or take more than one dose at a time.

What Medications Can Apriso Interact With?

Apriso should not be taken with antacids, as it can affect the ability of the drug to be released in the colon. Tell your doctor if you are taking:

Apriso may interact with other drugs that are not on this list. Always tell your physician about all the drugs and supplements you are taking.

Are There Any Food Interactions I Should Be Aware Of?

There are no known food interactions with Apriso.

Sources:

Salix Pharmaceuticals, Inc. "About APRISO." Apriso-UC.com 2009. 23 Jan 2013.

Waknine Y. "FDA Approvals: Apriso, Promacta, Treanda." Medscape 4 Dec 2008. 26 Feb 2013.

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