Digestive Health Inflammatory Bowel Disease Treatment Prednisone Frequently Asked Questions By Amber J. Tresca Updated on July 31, 2023 Medically reviewed by Robert Burakoff, MD Fact checked by Heather Mercer Print Prednisone is a type of drug known as a corticosteroid. It closely resembles a substance that is made by the human adrenal glands. Steroids are made naturally by the human body and work to reduce inflammation, regulate metabolism, and moderate the immune response. The body produces more steroids when it is stressed, such as during an illness. This is why they are sometimes referred to as "stress hormones." Prednisone is prescribed to treat many different types of inflammatory conditions, everything from skin rashes to inflammatory bowel disease (IBD). Prednisone may be given for only a short time, such as over a few days to much longer periods. Some people who take prednisone for chronic conditions have trouble stopping the drug because the symptoms return every time the dose is lowered. This is called steroid-dependent, and most healthcare providers agree it's not an optimal form of treatment. In most cases, getting the condition under control and stopping the prednisone as soon as possible is the ultimate goal. Getty Images / Jose Luis Pelaez Inc What Are the Side Effects of Prednisone? Side effects of prednisone that can prove troublesome include increased appetite, weight gain, acne, mood changes, and difficulty sleeping. The more serious side effects of prednisone include cataracts, glaucoma, osteoporosis, and bone damage in the hips. These side effects are permanent and occur only after long-term use. If you have concerns about these side effects, you should speak to your practitioner regarding these risks. How Is Prednisone Taken? Prednisone should be taken exactly as prescribed by the healthcare provider. A practitioner will tailor the dosage to the needs of each individual patient. In order for prednisone to have the desired effect on the body, it must be taken at certain regular intervals. DO NOT stop taking prednisone suddenly without consulting your healthcare provider. Prednisone is a drug that must be tapered down slowly over a number of days, and in some cases, even over weeks or months. The length of time it takes to stop the prednisone will be dependent upon how long it was taken in the first place: If it's only taken for a few days or weeks, a taper might not be needed. In order to prevent the stomach upset that sometimes occurs with prednisone, it can be taken with a meal or a snack. Why Is Prednisone Prescribed? Prednisone may be prescribed for many conditions including Crohn's disease and ulcerative colitis, allergic rhinitis (hay fever), rheumatoid arthritis, and ankylosing spondylitis. What Do You Do If You Miss a Dose? If you miss a dose, take it as soon as you remember. If your next dose of prednisone should be taken soon, just take that dose. Don't double up, or take more than one dose at a time. Precautions Taking prednisone can be problematic in certain circumstances. Tell your healthcare provider if you have ever had any of the following: Depression or other mood disorder Glaucoma High blood pressure Hyperglycemia or diabetes Osteoporosis Seizures Systemic fungal infection* Tuberculosis (active or inactive) Viral infection such as herpes infection of eyes, lips, or genitals *A systemic fungal infection is a contraindication for prednisone use. The others on this list have warnings associated with them. What Medications Can Prednisone Interact With? Prednisone may interact with the following medications: Antibiotics (fluoroquinolones, isoniazid, rifampin, troleandomycin)Antidepressants (bupropion, quetiapine)Antifungals (ketoconazole, fluconazole)Antivirals (ritonavir)Blood thinners (warfarin)Cholesterol-lowering medications (cholestyramine)Diabetes medicationsDiuretics ("water pills")Ephedrine (found in cold medications)EstrogenHeart medications (digoxin)Live vaccines (measles, chickenpox)Pain relief (NSAIDs, aspirin)Seizure medications (phenobarbital, phenytoin) Can You Take Prednisone With Advil (Ibuprofen)? Is Prednisone Safe During Pregnancy? The FDA has classified prednisone as a type C drug. This means that it is not known exactly what effect it has on a fetus when taken during pregnancy. Notify the prescribing healthcare provider if you become pregnant while taking prednisone. Prednisone does pass into breast milk and could affect a nursing infant. How Long Can Prednisone Be Taken Safely? In most cases, it is advisable to taper off prednisone as soon as symptoms subside. 13 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Oakley RH, Cidlowski JA. The biology of the glucocorticoid receptor: New signaling mechanisms in health and disease. J Allergy Clin Immunol. 2013;132(5):1033-1044. doi:10.1016/j.jaci.2013.09.007 University of Michigan Health. Prednisone. Liu D, Ahmet A, Ward L, et al. A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy. All Asth Clin Immun. 2013;9(1):30. doi:10.1186/1710-1492-9-30 Johns Hopkins Vasculitis Center. Prednisone. Fields TF. Steroid side effects: How to reduce drug side effects of corticosteroids. Hospital for Special Surgery. 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Annals of the Rheumatic Diseases. 2014;73(1):243-246. doi:10.1136/annrheumdis-2012-203055 MedlinePlus. Prednisone. DailyMed. Prednisolone. Van Matre ET, Satyanarayana G, Page II RL, Levi ME, Lindenfeld J, Mueller SW. Pharmacokinetic drug–drug interactions between immunosuppressant and anti-infective agents: antimetabolites and corticosteroids. Ann Transplant. 2018;23:66-74. doi:10.12659%2FAOT.906164 Ryu RJ, Easterling TR, Caritis SN, et al. Prednisone pharmacokinetics during pregnancy and lactation. The Journal of Clinical Pharmacology. 2018;58(9):1223-1232. doi:10.1002/jcph.1122 By Amber J. Tresca Amber J. Tresca is a freelance writer and speaker who covers digestive conditions, including IBD. She was diagnosed with ulcerative colitis at age 16. See Our Editorial Process Meet Our Medical Expert Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit