Definition: A granuloma is a microscopic collection of cells which form during an infection or inflammatory state. It cannot be seen during a colonoscopy because it is not a visible mass or nodule.
Granulomas are not specific to Crohn's disease, but if seen are helpful in distinguishing between ulcerative colitis and Crohn's disease. But when a granuloma is found, and the patient has symptoms consistent with Crohn's disease, it can help a physician make a diagnosis of Crohn's disease. Granulomas are not seen on intestinal or colonic biopsies of patients with ulcerative colitis.
Pronunciation: gran-yoo-LO-muh
